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Updated: Sep 9, 2025

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整体脳測定から回路特有の精度まで:リウマチ性関節炎におけるTNF阻害剤反応のためのfMRIバイオマーカーの進歩 - 著者の回答

Andreas Hess1, Koray Tascilar2, Georg Schett2

  • 1Institute of Pharmacology and Toxicology, Erlangen, Germany; Department of Neuroradiology, Erlangen, Germany; FAU NeW-Research Center New Bioactive Compounds, Erlangen, Germany; Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

The Lancet. Rheumatology
|August 30, 2025
PubMed
まとめ

No abstract available in PubMed .

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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