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Updated: May 2, 2026

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アルコールは,ATF4/LPLA2媒介のBMP代謝を活性化し,HBV誘発の肝細胞発がんを促進する

Haoxiong Zhou1, Junhui Ba2, Chuyu Xiao1

  • 1Department of Gastroenterology, Alcohol-related Liver Disease Center, The Third Affiliated Hospital of Sun Yat-Sen University, 510630 Guangzhou, China; Guangdong Provincial Key Laboratory of Liver Disease Research, 510630 Guangzhou, China.

Journal of hepatology
|August 30, 2025
PubMed
まとめ

慢性的なアルコール摂取は,ATF4/LPLA2媒介のBMP代謝を活性化することによって,HBV誘発の肝がんを促進する. LPLA2またはBMP代謝をターゲットにすることで,がんの進行を抑制し,肝細胞癌 (HCC) の新しい治療戦略を提供することができる.

キーワード:
ATF4 についてアルコールBMP についてHBV ウイルスLPLA2 について肝細胞がん

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