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CAR細胞療法の治療効果を改善するために代謝を調節する:ベンチからベッドサイドまで

Dengxiong Li¹, Jie Wang², Ruicheng Wu³

¹Department of Urology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang Province, China; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.

Metabolism: clinical and experimental

|August 30, 2025

まとめ

腫瘍微環境 (TME) の代謝因子は,キメリック抗原受容体 (CAR) T細胞治療の有効性を阻害する. TMEの代謝をターゲットにすることで,CAR T細胞の機能を向上させ,がん治療の改善のために抵抗を克服することができます.

科学分野:

免疫学
メタボリック・エンジニアリング
腫瘍学

背景:

化学抗原受容体 (CAR) T細胞治療は,耐火性がんの治療に有望である.
腫瘍の微小環境 (TME) の代謝は,CAR T細胞の機能と治療抵抗性に重大な影響を及ぼします.
TMEの代謝問題,特に固体腫瘍に関する理解は限られている.

研究の目的:

CAR T細胞治療の結果に影響を与える代謝メカニズムをレビューする.
TMEの代謝プロセスがCAR T細胞治療の失敗にどのように寄与するかを調べる.
CAR T細胞療法における代謝障害を克服するための戦略を特定する.

主な方法:

PubMedとWeb of Scienceからの研究を総合的に分析したものです
低酸素,糖分分解,コレステロール代謝などの代謝プロセスに注目してください.
TME内のCAR T細胞相互作用の検討

主要な成果:

TMEの代謝因子である低酸素と乳酸は,CAR T細胞の細胞毒性,増殖,および幹性を阻害する.
腫瘍細胞,ストロマ細胞,細胞外マトリックスとの相互作用により,免疫抑制性TMEが生じる.
CAR T細胞の有効性は,血液学的および固体腫瘍の両方の代謝経路によって著しく影響されます.

結論:

代謝は,CAR T細胞の抗腫瘍効果を決定する重要な要因である.
TMEの代謝経路をターゲットにすることで,CAR T細胞の浸透,機能,および持続性を高めることができます.
代謝の障壁を克服することで CAR T細胞治療の成果を向上させより効果的ながん治療が可能になります

キーワード:

CAR細胞療法抗がんメカニズム代謝の調節合成生物学腫瘍の微小環境

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