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Updated: Sep 9, 2025

Direct Detection of the Acetate-forming Activity of the Enzyme Acetate Kinase
05:51

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Published on: December 19, 2011

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菌類のアセチルCoA合成酵素の阻害剤としてのアシルAMPリン酸イソステルの合成と評価

Drashti G Daraji1, Andrew J Jezewski2, Katy M Alden2

  • 1Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, IL, 60115, United States.

Bioorganic & medicinal chemistry letters
|August 30, 2025
PubMed
まとめ

アセチル-コア合成酵素 (ACS) は病原菌に不可欠であり,その抑制は有望な抗感染戦略である. 研究者は新しい阻害剤を合成しテストし,化合物14は将来の薬剤設計のための構造的洞察を提供しました.

キーワード:
アシルAMPクリスタル構造酵素阻害菌類のアセチル-コア合成酵素 (ACS)分子ドッキングリン酸イソステル合成

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