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Updated: Sep 9, 2025

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
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腫瘍免疫療法のための血液生成原始キナーゼ1 (HPK1) を標的とする:小分子阻害剤の進歩

Adili Tuersun1, Xin Zhao2, Alimu Aikebaier3

  • 1School of Pharmaceutical Sciences, State Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Fudan University, Shanghai 201203, China.

Biochemical pharmacology
|August 30, 2025
PubMed
まとめ

免疫反応をネガティブに制御する. HPK1を阻害すると,抗腫瘍免疫力が強化され,がんの免疫療法開発において有望な標的となる.

キーワード:
癌についてクリスタル構造ヘマトポエティックプロジェニターキナーゼ1免疫療法インヒビータ

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