関連する実験動画

Updated: May 5, 2026

Generating Self-Assembling Human Heart Organoids Derived from Pluripotent Stem Cells
08:56

Generating Self-Assembling Human Heart Organoids Derived from Pluripotent Stem Cells

Published on: September 15, 2021

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プランバギンはCYP2J/ EETsの代謝経路を阻害し,心臓器官とネズミの心臓損傷を引き起こす

Chenmeizi Liang1, Qifan Qi1, Bingyi Yao1

  • 1Changning Maternity and Infant Health Hospital and School of Life Sciences, Shanghai Key Laboratory of Regulatory Biology, East China Normal University, Shanghai, China.

Biochemical pharmacology
|August 30, 2025
PubMed
まとめ

プランバギンは,保護性エポキシエコサトリエノ酸 (EET) を減少させるサイトクロームP450 2J (CYP2J) 酵素を阻害することで心臓損傷を引き起こす. このCYP2J/ EETs経路の障害は心臓損傷につながる.

キーワード:
心臓器官心臓毒性サイトクロームP450 2J (CYP2J)エポキシエコサトリエノ酸 (EET)プルンバギン

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