関連する実験動画

Updated: Sep 9, 2025

Mapping the Binding Site of an Aptamer on ATP Using MicroScale Thermophoresis
08:09

Mapping the Binding Site of an Aptamer on ATP Using MicroScale Thermophoresis

Published on: January 7, 2017

10.7K

テルミサルタンとヒトチオプリンSメチルトランスフェラーゼの結合ダイナミクスと相互作用に関するメカニズム的洞察

Archana Vakkayil1, Deepthi Jose2, Tom Skaria1

  • 1Department of Bioscience and Engineering, National Institute of Technology Calicut, Calicut, Kerala, India.

Journal of pharmaceutical sciences
|August 30, 2025
PubMed
まとめ

テルミサルタン薬は,免疫抑制剤の処理に不可欠な酵素であるチオプリンSメチルトランスファーゼ (TPMT) と危険な相互作用を起こす可能性があります. この相互作用は,両方の薬を服用している患者で重篤な合併症を引き起こす可能性があります.

キーワード:
有害な相互作用コファクター結合ダイナミクス免疫代謝テルミサタンチオプリンS-メチルトランスフェラーゼチオプリン 毒性

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Protein-Drug Binding: Mechanism and Kinetics

Protein-drug binding refers to the interaction between drugs and proteins within the body. This binding process can occur intracellularly, involving drug interactions with enzymes or receptors within cells, or extracellularly, involving plasma proteins in the blood.
Various forces drive these interactions, including hydrogen bonds, hydrophobic interactions, ionic bonds, electrostatic interactions, and van der Waals forces. These bonds enable drugs to bind to specific sites on proteins,...
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Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
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Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
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