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Updated: Sep 9, 2025

Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease
06:04

Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease

Published on: February 9, 2016

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PermeaPadTMプレートを使用して,ソリフェナシンの腸内浸透性に対する粘液層,胆酸,および医薬品の補助物質の影響を調査

Yuki Hagiwara1, Kouichi Yoshinari2

  • 1Analytical Research Laboratories, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan; Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

Journal of pharmaceutical sciences
|August 30, 2025
PubMed
まとめ

ソリフェナシン (SOL) の腸内浸透性は,タウロコル酸 (TCA) と粘液層の相互作用によって影響を受ける. PermeaPadTMプレート (PPP) は,開発中の薬剤の透過性評価のための実行可能な代替案を提供します.

キーワード:
複雑化インビトロモデル腸内吸収パッシブな拡散貫通性粘膜経由による薬物投与

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