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Updated: Sep 9, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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小型のイミダゾール由来リガンドは,KRASプロモーターG-クアドルプレックスと結合し,免疫調節を強化して癌の成長を抑制する

Xiao-Dong Wang1, Qian-Wen Nie1, Ming-Hao Hu1

  • 1Nation-Regional Engineering Lab for Synthetic Biology of Medicine, International Cancer Center, School of Pharmacy, Shenzhen University Medical School, Shenzhen 518060, China.

The Journal of biological chemistry
|August 30, 2025
PubMed
まとめ

研究者らは,腫瘍の成長を抑制するために,KRAS G四重複体を標的とする新しい小分子BN1を開発しました. この薬剤のような化合物は,免疫細胞とサイトカインを調節することによって,腫瘍の負荷を効果的に軽減し,抗腫瘍免疫力を強化しました.

キーワード:
KRAS G-クアドルプレックス免疫調節ブロードスペクトル阻害剤

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