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Updated: Sep 9, 2025

Analysis of SCAP N-glycosylation and Trafficking in Human Cells
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心筋病で変異したトランスメブランタンパク質によるSREBPの抑制

Yasushi Takemoto1, Manchir Tserendagva1, Motonari Uesugi2

  • 1Institute for Chemical Research, Kyoto University, Uji, Kyoto, 611-0011, Japan.

The Journal of biological chemistry
|August 30, 2025
PubMed
まとめ

TMEM43タンパク質は,不律性右心室性心筋病変 (ARVC) の病原性における重要なプロセスであるSREBPsを阻害することによって,心臓細胞の脂肪生成を抑制する. この発見はTMEM43を明らかにしています.

キーワード:
SREBP についてTMEM43 についてアディポゲネシス心筋病脂質合成トランスクリプションコアクティベーター転写規制について

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