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Updated: Sep 9, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

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NFE2L2は,HO1/フェリチン経路を活性化することによって,ソラフェニブ誘発のフェロプトーシスと心臓毒性から保護する

Hui Jiang1, Yan Su2, Yinglong Hou3

  • 1Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, China; Department of Pediatrics, The Second Hospital of Shandong University, Jinan, Shandong 250012, China.

Toxicology and applied pharmacology
|August 30, 2025
PubMed
まとめ

転写因子NFE2L2は,HO-1/フェリチン経路を活性化することによって,ソラフェニブ誘発の心臓毒性から保護し,薬物誘発の心臓損傷を軽減するための新しい治療戦略を提供します.

キーワード:
薬剤による心臓毒性フェリチンフェロプトーシスHO-1 についてNFE2L2 についてソラフェニブ

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