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Updated: Sep 9, 2025

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

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オレウロペインとのKEAP1/NRF2の相互作用をターゲットにすることで,マクロファージのフェロプトーシスを抑制することで,動脈硬化が改善されます

Xinxin Zhu1, Yuwu Chen1, Biyi Xu1

  • 1Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), No. 246 Xuefu Road, Nangang District, Harbin, 150001, China; The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, 150001, China.

Free radical biology & medicine
|August 30, 2025
PubMed
まとめ

オレウロペイン (OL) は,マクロファージのフェロプトーシスを防止することによって,動脈硬化から保護します. この動脈疾患に対する新しい治療戦略を提供するKEAP1への競争的結合を通じてNRF2の活性化を促進することによって達成されます.

キーワード:
動脈硬化症フェロプトーシスマクロファージNRF2/KEAP1複合体についてオレロペイン

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