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Updated: Jul 12, 2026

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
07:09

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

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新しいアンジオテンシンII型2受容体アンタゴニストTDI05は,周辺神経疾患の痛みを軽減します

Qilong Mao1, Yu Zeng2, Huining Liang3

  • 1Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Taiyuan 030001, China; State Key Laboratory of Complex, Severe, and Rare Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China; State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.

Neuroscience letters
|August 30, 2025
PubMed
まとめ

TDI05はアンジオテンシンII型2受容体 (AT2R) 反抗体であり,炎症を軽減し,痛みに関連するイオンチャネルを抑制することによって神経疾患の痛みを効果的に治療します. 臨床前モデルでは,この新薬が有意な鎮痛効果を示しています.

キーワード:
アンジオテンシンII炎症神経疾患の痛みアンジオテンシンII型2受容体

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