心筋細胞の mitochondrial mono-ADP-ribosylationは,雄性マウスのバイオエネルギー準備を構成することによって,心臓のセプシス耐性を決定する

Xiaoqiang Chen1,2, Tianyou Yuan1, Danchuan Zheng1

  • 1Department of Cardiology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Nature communications
|August 30, 2025
PubMed
まとめ

心筋細胞におけるマクロD1酵素を阻害すると,ミトコンドリア複合体Iの活性が保たれ,心臓の機能が改善されます. この発見はセプティック心筋病の 治療対象となる可能性がある.

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