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Updated: Sep 9, 2025

Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
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Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

Published on: May 30, 2012

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大腸がんの再発を遅らせる強力なアゴニストベースのPROTACで妊娠中のX受容体をターゲットにする

Lucile Bansard1, Guillaume Laconde2, Vanessa Delfosse3

  • 1Institute of Functional Genomics (IGF), Univ. Montpellier, Inserm, CNRS, Montpellier, France.

Oncogenesis
|August 30, 2025
PubMed
まとめ

新しいPROTAC分子であるJMV7048は,がん細胞のPregnane X受容体 (PXR) を標的とし,分解する. このアプローチは,化学療法に抵抗する腫瘍を治療に再敏感にし,臨床前モデルの癌の再発を防ぐ.

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