幼児期における腸のレジストームを形成する時間的動態と微生物の相互作用
Ioanna Chatzigiannidou1, Pi L Johansen1, Rasmus K Dehli1
1Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark.
Nature communications
|August 30, 2025
まとめ
乳児の腸内抗生物質耐性遺伝子は 6ヶ月でピークに達します ビフィドバクテリアのような有益なバクテリアの促進は,ARGを減少させ,生命の初期に抗菌剤耐性 (AMR) に対する戦略を提供します.
科学分野:
- 微生物学
- ゲノミクス
- 小児科
背景:
- 腸内レジストームは,抗菌剤耐性 (AMR) の拡散において重要な役割を果たします.
- 乳児の腸内微生物群における抗生物質耐性遺伝子 (ARG) を減少させる戦略は十分に研究されていない.
- 幼児期は腸内微生物群の発達とAMRの確立にとって重要な時期です.
研究 の 目的:
- 幼児の腸内微生物群におけるARGの動態を研究する.
- 乳児におけるARGの量と組成に影響を与える要因を特定する.
- 人生の初期に抗菌剤耐性を抑制するための潜在的な介入を探る.
主な方法:
- 乳児の腸内微生物群の縦断的な定量的なメタゲノミクス分析
- ARGの豊富さと富を時間とともに追跡する.
- バクテリア分類,ARG,および代謝産物間の相関分析.
主要な成果:
- 乳児の腸内微生物群は 生後1週間から検出され,ピークは6ヶ月です.
- 胎児の出産モードは早期のARGの動態に影響し,陰道出産はより高いARG濃度に関連しています.
- エシェリキア・コライ菌株の母からの感染は,乳児のARG負荷に寄与する.
- アロマティックミルク酸を生成するビフィドバクテリアは,E. coliのようなARGに富んだ種と逆相関する.
- アロマティックミルク酸は,E. coliや他の機会性ARG豊富なバクテリアのインビトロ増殖を抑制する.
結論:
- テンポラル微生物の相互作用が 乳児の腸内レジストームを大きく形作ります
- アロマティックミルク酸を生成するビフィドバクテリアの植民を促すことは,幼児期にARGを減らすための潜在的な介入戦略です.
- 早期の微生物の発達をターゲットにすることで 抗菌剤耐性の拡大を抑制できます
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