食事による炎症指数と後の食事パターンと肺がんリスクとの関連に関するコホート研究
Qing Zhou1,2, Zhongwen Gong1,2, Yongjia Li1,2
1Center for Lipid Research, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), The Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Scientific reports
|August 30, 2025
まとめ
食事による炎症指数 (DII) の上昇は,肺がんのリスクの増加と相関しています. 逆に 果物や野菜を多く摂取すると このリスクが低下し 食事と炎症と肺がんの予防との関連が示唆されます
科学分野:
- 栄養学
- 腫瘍学
- 流行病学
背景:
- 食生活は癌を含む慢性疾患のリスクに大きな影響を与えます
- ダイエット炎症指数 (DII) は,ダイエットの炎症の可能性を定量化します.
- 食事パターン 炎症 肺がんの相互作用を理解することは 公衆衛生にとって極めて重要です
研究 の 目的:
- ダイエット炎症指数 (DII) と肺がんリスクとの関連を調査する.
- 特定の食事パターンと肺がんの発生率の関係を探る
- 肺がんリスクの文脈で食事パターンがDIIとどのように相互作用するかを調べる.
主な方法:
- イギリスのバイオバンクデータを用いた前向きなコホート研究 (189,561人).
- 24時間の食事リコールアンケートで評価された食事摂取量
- 統計的分析には,スピアーマンの相関,コックスの比率的な危険性回帰,および食事パターンを特定するための因数分析が含まれていた.
主要な成果:
- DIIが高かったと肺がんのリスクが高かった (HRT3対T1: 1. 17).
- 果物と野菜の食生活は,肺がんリスクの低下と関連していた (HRT3 vs. T1: 0. 78).
- 肉に富んだ食事パターンは肺がんのリスクが高いことを示した (HR T3 vs T1: 1.18) が,穀物/加工食品は有意な関連性を示さなかった.
結論:
- DIIで測定された食事による炎症の可能性は,肺がんを発症するリスクの高さに関連しています.
- フルーツと野菜を食事に含めると 肺がんのリスクが軽減され 食事による炎症の負荷が軽減される可能性があります
- 食事の選択は肺がんの病因において重要な役割を果たし,予防戦略の機会を強調しています.
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