関連する実験動画

Updated: Sep 9, 2025

Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e
07:31

Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e

Published on: February 17, 2023

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傍観者の編集を減らすための精簡化されたベースエディタエンジニアリング戦略

Izabella Valdez1,2,3, Ian O'Connor1,3, Divesh Patel4

  • 1Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Nature communications
|August 30, 2025
PubMed
まとめ

研究者らは,遺伝子疾患の治療における精度を高めるために,より狭い編集ウィンドウを持つ新しいベースエディター (BE) を設計した. この改良された塩基編集技術は 標的外変異を減少させ より安全で効果的な治療手段となります

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