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Updated: Sep 9, 2025

ACT1-CUP1 Assays Determine the Substrate-Specific Sensitivities of Spliceosomal Mutants in Budding Yeast
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PYM1は,mRNA発現を調整するために,遺伝子構造に依存する方法で,非正規のエクソン・ジャンクション・コンプレックス占有量を制限する

Manu Sanjeev1,2, Lauren A Woodward1, Michael L Schiff3

  • 1Department of Molecular Genetics, The Ohio State University, Columbus, OH, 43210, USA.

Nature communications
|August 30, 2025
PubMed
まとめ

エクソン・ジャンクション・コンプレックス (EJC) の解体因子PYM1は,トランスレーションとは無関係にEJCを不安定化する. PYM1は非正規のEJCを制限し,宿主mRNAの調節を変えるためにフラビウイルスによってハイジャックされた機能です.

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