健康な被験者における努力に基づく意思決定と無関心に関連するフロントモーター回路
Gerard Derosiere1,2, Pierre Vassiliadis3, Laurence Dricot4
1Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium. gerard.derosiere@inserm.fr.
Communications biology
|August 30, 2025
まとめ
この研究は 脳の回路の接続が 努力にどう影響し 無関心な決断に 報酬を与えるかを明らかにしています 発見は無関心と動機付けられた行動に関連した特定の経路を強調し,新しい治療目標を示唆しています.
科学分野:
- 神経科学
- 認知神経科学
- 神経学
背景:
- 無関心は,努力に基づく意思決定の障害と,フロント・ベース・ギャングリア (BG) の回路の変化を伴う.
- 前回の無関心と意思決定に関する研究は,フロント-BG-M1回路の接続を完全に調査していません.
研究 の 目的:
- フロント-M1,フロント-BG-M1,およびM1内での構造的および効果的な接続性を無関心に関連して調査します.
- 脳回路の測定値と 努力と報酬の評価の計算パラメータの関連性を調べる
主な方法:
- トラクトグラフィーとペアパルス経頭蓋磁気刺激を 45人の健康な参加者に施しました
- アパシースコアと意思決定行動の計算モデルに関連した接続性測定値.
主要な成果:
- アパシースコアは 軌道前皮質の構造的および効果的な接続性と相関しています
- 補足的なモーター領域回路に関連した努力評価;M1内GABAergic回路に関連した報酬評価.
結論:
- 分離可能な回路レベルの貢献は 動機付けられた行動の異なる側面を裏付けています
- 無関心症の治療のための潜在的な神経調節標的を特定した.
さらに関連する動画
09:14Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
344
10:33Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis
Published on: June 20, 2012
12.9K
関連する概念動画
Direct Motor Pathways
2.4K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
2.4K
Decision Making
228
Decision-making is a fundamental cognitive process that involves evaluating alternatives and selecting among them. This process can range from simple choices, such as deciding what to wear, to complex decisions, like choosing a major in college or a career path. The complexity of the decision often dictates the approach we use, which can be broadly categorized into two types: automatic and controlled decision-making.
Automatic decision-making is fast, intuitive, and relies on gut feelings...
Automatic decision-making is fast, intuitive, and relies on gut feelings...
228
Association Areas of the Cortex
6.2K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
6.2K
Motor and Sensory Areas of the Cortex
4.6K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
4.6K
