アピゲニンは,AKTシグナル伝達経路を調節することによって,結血症における腸壁機能障害を軽減する

Zheng Lijun¹, Wang Liping², Zhao Dandan³

¹Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, 350122, China.

BMC gastroenterology

|August 30, 2025

まとめ

アピゲニンは天然のフラボノイドで腸の壁を強め炎症を軽減することでセプシスから守りますセプシスによる臓器損傷と闘う可能性を明らかにした.

科学分野:

生物医学
薬理学について
免疫学

背景:

セプシスは生命を脅かす病気で感染に対する宿主体の反応が調節されず臓器の機能不全を引き起こします
腸内障壁はホメオスタシスの維持に不可欠で腸内障壁の破損はセプシスの特徴です
自然成分はセプシスの治療に役立つ可能性があります

研究の目的:

セプシス中の腸壁機能に対するアピゲニンの保護効果を調査する.
アピゲニンの根底にある抗炎症と防護メカニズムを解明する.
セプシスの文脈でアピゲニンの主要な分子標的を特定する.

主な方法:

マウンのセプシスモデルとCaco-2細胞系を用いた.
アピゲニン治療による腸の透過性 (FITC- デクストランアッセイ) と緊密結合タンパク質発現の影響を評価した.
系統的炎症マーカー (IL-6,TNF-α) と主要タンパク質標的 (MMP- 9,COX- 2) を定量化した.

主要な成果:

アピゲニン治療は腸壁の整合性を大幅に改善しました.
アピゲニンは,炎症誘発性サイトカインIL-6とTNF-αの血清濃度を低下させた.
アピゲニンはMMP- 9とCOX- 2の発現を抑制し,AKT1とMMP- 9を標的とした.

結論:

アピゲニンは,セプシス中の腸のバリア機能を効果的に保ちます.
アピゲニンは,抗炎症とバリア修復の組み合わせにより,保護効果を発揮する.
アピゲニンはセプシスの治療の可能性を示しています.

キーワード:

アピゲニンカカオ-2 腸内障壁ネットワーク薬理学セプシス

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