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Updated: Sep 9, 2025

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
09:45

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Published on: August 21, 2019

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E2F1-オートファギー-ALDH1A1軸は,肺がん幹細胞の自己再生と薬剤耐性をp53依存的に強化する

Jingyuan Li1, Yiyu Chen1, Jianyu Wang2

  • 1Department of Laboratory Medicine, the Affiliated Hospital of Southwest Medical University, No. 25, Taiping Street, Jiangyang District, Luzhou, Sichuan, 646000, P. R. China.

Journal of experimental & clinical cancer research : CR
|August 30, 2025
PubMed
まとめ

転写活性化剤E2F1は,E2F1- 自閉症- ALDH1A1経路を通じてがん幹細胞の自己再生と薬剤耐性を強化することによって,肺腺がん (LUAD) の発症を促進する. これは,E2F1を LUADの潜在的な診断マーカーとして強調しています.

キーワード:
オートファジー薬剤耐性E2F1 について肺がん幹細胞自動更新p53 について

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