大気汚染が多胞性卵巣症候群の発生に及ぼす潜在的な影響:1990年から2021年までの171カ国・地域のグローバル分析
Yihao Chen1, Yangyang Dai1, Jiahua Qian2,3
1The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
Journal of ovarian research
|August 30, 2025
まとめ
二酸化窒素 (NO2) のような大気汚染物質への曝露は,多胞性卵巣症候群 (PCOS) の発生率の増加と関連しています. 大気汚染を減らすことで 全世界のPCOSの負担が 軽減されるかもしれません
科学分野:
- 環境 健康
- 流行病学
- 生殖 健康
背景:
- 多囊性卵巣症候群 (PCOS) の発生は,大気汚染と関連しているが,窒素二酸化物 (NO2) の変動の具体的な影響は不明である.
- この研究は,世界の大気汚染物質濃度とPCOSの負担との関連を調査しています.
研究 の 目的:
- 大気汚染,特にNO2濃度とPCOSの世界的な負担の関係を調べる.
- PCOSの発生率の増加に寄与する環境要因を特定する.
主な方法:
- 全世界の疾病負担2021データセットを利用し,171か国 (1990年-2021年) のPCOSの年齢標準化発生率 (ASIR) を分析した.
- 空気汚染物質 (NO2,SO2,PM,O3) とPCOSの負荷を評価するために,混合線形モデル,地理検出器,重量定数回帰,制限立方スライン回帰を使用した.
- NO2-PCOS関連に対する地域経済発展の影響を調査するためにサブグループ分析を実施した.
主要な成果:
- 混合線形モデルと地理検知器により,NO2,SO2,粒子状物質 (PM) とオゾン (O3) がPCOSASIR増加と関連していることが明らかになった.
- 空気汚染物質の濃度とPCOSの発生率との間に正の相関が観察されました.
- NO2濃度とPCOSASIR (P<0. 001) の間には非線形的な関連性が見られ,中高の経済地域ではより強い効果が見られた.
結論:
- 継続的な曝露と大気汚染物質の変動,特にNO2は,PCOSの負担を増加させる可能性があります.
- 空気の質の改善により,世界的にPCOSの負担が軽減される可能性があります.
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