腸不全の子供のヨーグルトの中央線に関連する血流感染症の症例
Nasiha Rahim1, Emily Keller2, Ellen Wagner3
1Section of Gastroenterology, Hepatology & Nutrition, Comer Children's Hospital, University of Chicago, Chicago, Illinois, USA.
まとめ
腸機能不全の幼児は 摂取したヨーグルトに含まれるラクトバチルス種による 中央線関連血流感染症 (CLABSI) を発症した. このケースは 乳酪の摂取と 免疫不全の子供のCLABSIとの間にある 希少な関連性を強調しています
科学分野:
- 子供 の 感染症
- 胃腸内科
- 微生物学
背景:
- 中枢線に関連した血流感染症 (CLABSI) は,小腸不全 (IF) の小児における深刻な合併症である.
- 細菌血症のリスクがあるため,プロバイオティクスの使用は一般的に避けられます.
- 乳球菌種は一般的なプロバイオティクスであり,腸内共生菌であるが,CLABSIの原因はまれである.
研究 の 目的:
- IFを患った子供にCLABSIの新症例を報告する.
- この患者集団におけるヨーグルト摂取とCLABSIの関連性を調べる.
- 脆弱な小児群の異常な感染を記述する.
主な方法:
- 幼い子供に IFとCLABSIの疑いがある
- 中枢静脈カテーテルと周辺から採取した血液培養物.
- 血液と消費されたヨーグルトからのラクトバチルス単離の比較遺伝子解析
主要な成果:
- 血液培養で確認された熱と血流の感染症.
- 中央線と周辺の培養は,ラクトバチルス種が育った.
- 遺伝子分析では,CLABSIの単離とギリシャヨーグルトのラクトバチルスとの間で高い類似性 (~99%) が示された.
結論:
- このケースは,日々のギリシャヨーグルトの摂取と,IFの子供におけるLactobacillus CLABSIとの間の関連を示唆しています.
- 潜在的な感染経路は,CVCの汚染または胃腸の転移です.
- これはヨーグルト摂取に関連したIF患者のCLABSIの最初の報告例です.
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