関連する実験動画

Updated: Sep 9, 2025

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
05:15

Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Published on: February 6, 2019

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サイクリックイミンのキラルリン酸触媒によるラサギリンのエナンチオセレクティブ・グラムスケール合成

Hayate Ishizuka1, Toma Osawa1, Yuta Shimizu1

  • 1Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16, Naka-cho, Koganei, Tokyo, 184-8588, Japan.

Chemistry, an Asian journal
|August 31, 2025
PubMed
まとめ

ラサジリンメシラートの新しいエナチオセレクティブ合成経路は,サイクリックイミンの非対称的移転水素化 (ATH) を用いて開発された. このスケーラブルな方法は,パーキンソン病の薬剤合成のための実用的な代替案を提供して,高い収穫量とエナチオ選択性を提供します.

キーワード:
非対称な水素転送キラルリン酸周期的なイミンハンツシュエスターラサギリン

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