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Updated: Sep 9, 2025

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Oral Health Assessment by Lay Personnel for Older Adults
Published on: February 2, 2020
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高齢者における血清ホロトランスコバラミンの相関値
Paula Stürmer1, Eike Andreas Strathmann2, Tatjana Patricia Liedtke2
1Institute of Epidemiology, Kiel University, Niemannsweg 11, 24105, Kiel, Germany. paula.stuermer@epi.uni-kiel.de.
European journal of nutrition
|August 31, 2025
まとめ
ホロトランスコバラミン (holo- TC) レベルは,ビタミンB複合体のサプリメント,乳製品,魚の摂取によって影響を受けます. 性,コレステロール,血圧,アルコールの消費も一般集団の研究でホロ-TCと相関しています.
科学分野:
- 栄養学的生化学
- 臨床化学
- 人口の健康
背景:
- ホロトランスコバラミン (holo- TC) は,健康に不可欠なビタミンB12の活性形態です.
- 重度の欠乏症は知られているが,生理学的ホロ-TCの範囲とその相関は十分に研究されていない.
- ビタミンB12は主に動物由来食品に含まれています.
研究 の 目的:
- 血清ホロTCと代謝,ライフスタイル,食事の因子の横断的関連を調べる.
- 一般集団のサンプル内でホロ-TCの主要な相関性を特定する.
主な方法:
- 788人の個体で電気化学発光で測定された血清ホロ-TC.
- 有意な代謝とライフスタイルの相関を特定するために使用される線形回帰モデル.
- 乳製品,卵,魚,肉の摂取量を評価した.
主要な成果:
- アラニンアミノトランスフェラーゼ,総コレステロール,アルコール摂取量の上昇はホロ-TCの増加と関連していました.
- 静脈血圧はホロ-TCと 負の関係を示した.
- ビタミンB複合体の補充と女性の性別は,より高いホロ-TCレベルに関連していました.
- 乳製品と魚/海産物の摂取量が増加すると,特に魚のオスではホロ-TCが高くなります.
結論:
- ビタミンB複合体,乳製品,魚は,ホロ-TCに反映されるビタミンB12の状態に大きく貢献しています.
- 血清のホロ-TCレベルは性行為,総コレステロール,腹圧,アルコール摂取と関連しています.
- これらの発見は,一般の人々のビタミンB12状態に影響を与える要因の洞察を提供します.
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