食中の単不飽和脂肪酸と胃がんのリスクとの関連
Ngoan Tran Le1, Yen Thi-Hai Pham2,3,4, Linh Thuy Le5
1Institute of Research and Development, Duy Tan University, Da Nang, Vietnam.
European journal of nutrition
|August 31, 2025
まとめ
単不飽和脂肪酸 (MUFA) の摂取量が高いと,ベトナムでは胃がんのリスクが低かった. これらの発見は,特に資源の限られた環境では,MUFAが豊富な食事が胃がんの予防に役立つことを示唆しています.
科学分野:
- 栄養学
- 胃腸内科
- 腫瘍学
背景:
- モノ不飽和脂肪酸 (MUFA) は,抗酸化物質やコレステロールを低下させるような有益な性質を持っています.
- MUFAの摂取量と胃がんのリスクに関する既存の証拠は,さまざまな集団で矛盾しています.
- 食事のパターンは民族によって大きく異なるため,人口特有の研究が必要である.
研究 の 目的:
- MUFAの摂取と胃がんのリスクとの関連を調査する.
- 食事の組成における潜在的な民族的差異を考慮して,ベトナム人人口内のこの関係を評価する.
主な方法:
- 1182人の胃がん患者と2965人の対照群を対象に,病院での症例対照研究が行われました.
- 単不飽和脂肪酸 (MUFA) の摂取量は,準量的な食品頻度アンケート (FFQ) を用いて評価された.
- 無条件のロジスティック回帰モデルは,オッズ比 (OR) と95%信頼区間 (CI) を計算するために使用されました.
主要な成果:
- MUFAの摂取と胃がんのリスクとの間には逆の関連性が見られた (OR per SD increment = 0. 75; P- trend < 0. 001).
- MUFA摂取量の高いクインティルは,胃がんの確率が徐々に低下し,最も高いクインティルは0. 43 (95%CI 0. 33- 0. 57) のORを示した.
- この逆の関係は,性別と異なる年齢層 (60歳以下と60歳以上) で一貫していました.
結論:
- 単不飽和脂肪酸 (MUFA) の摂取は,ベトナム人の胃がんリスクの低下と関連しています.
- MUFAの保護効果は,性別や年齢に関係なく観察されました.
- この発見は,低所得国,中所得国,その他の資源の限られた地域における胃がん予防戦略に重大な影響を及ぼします.
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