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STAT3/スナイルシグナリングと乳がん細胞における低酸素耐性の進行

Olga E Andreeva1, Danila V Sorokin2, Alexander M Scherbakov2,3

  • 1Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, 115522, Russia. tilberta@gmail.com.

Biochemistry. Biokhimiia
|August 31, 2025
PubMed
まとめ

乳がん細胞は,miR-181a-2/STAT3/Snail経路を活性化することで,酸素不足 (低酸素) に適応する. DNAメチル化を阻害することで,この低酸素耐性フェノタイプを逆転させ,新しい治療戦略を提供することができる.

キーワード:
STAT3 についてスナック乳がん低酸素メチル化miR-181a-2について

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