食事によるビタミンEの摂取は,代謝機能障害に関連したステアトーシス肝疾患の個体における死亡率の低下と関連している
Yajie Peng1, Wanhong Wu2, Lin Chen3
1Ministry of Education Key Laboratory of Metabolism and Molecular Medicine, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
Nutrition research (New York, N.Y.)
|August 31, 2025
まとめ
食事によるビタミンEの摂取量の増加は,代謝機能不全に関連した脂肪性肝疾患 (MASLD) の患者の死亡率の減少と関連しています. これは,ビタミンEがMASLD患者にとって有益な食事の介入である可能性があることを示唆しています.
科学分野:
- ヘパトロジー
- 栄養学
- 公衆衛生
背景:
- 代謝機能障害に関連した脂肪酸性肝疾患 (MASLD) は,世界的な健康上の懸念事項です.
- MASLDの管理には食事の変更が不可欠です.
- MASLD患者の死亡率に対するビタミンEの特定の影響については,さらなる説明が必要である.
研究 の 目的:
- MASLDと診断された患者の食事によるビタミンE摂取と死亡リスクとの関連を調べる.
- この集団におけるビタミンEの摂取量の増加が生存率の改善と相関するかどうかを判断する.
主な方法:
- 国家保健栄養調査 (NHANES) (1999年−2018年) と国家死亡指数 (NDI) のデータを活用した.
- 7883人のMASLD患者を含め,USDAの標準化された方法を使用してビタミンEの摂取量を評価した.
- カプラン・マイヤー曲線とコックス回帰モデルを用いて 複数の混同因子を調整した.
主要な成果:
- 食事によるビタミンEの摂取量の増加は,あらゆる原因による死亡リスクの減少と有意に関連していました.
- MASLD患者におけるビタミンEの摂取量の増加は,心血管疾患 (CVD) 死亡率の低下と相関していた.
- 保護効果は,非静止体や,総 bilirubin 値または肝臓の繊維が上昇した個体においてより顕著でした.
結論:
- 食事によるビタミンEの摂取は,MASLD患者における死亡率と有意な逆関係を示しています.
- 食中のビタミンEを増やすことは,MASLDの改善のための有望な予防戦略です.
- MASLDの治療介入としてビタミンEに関するさらなる研究が必要である.
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