サルコペニアの透析患者における伝統的な中国医学のシェン・キペーストの有効性と安全性: ランダム化,ダブルブラインド,プラセボ対照試験
Xiaoyan Li1, Rongyun Wang1, Keda Lu2
1School of Nursing, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China.
まとめ
伝統的な中国薬の Shen-Qi Paste (SQP) は,サルコペニアの透析患者で,筋肉質と身体機能を有意に改善しました. この研究では,SQPは,この集団における筋肉の消耗に対する有望な治療法であると示唆されています.
科学分野:
- ゲロントロジー
- 中国 伝統 医学
- 腎臓科
背景:
- サルコペニアは,特に透析患者において,重要な満たされていない医療ニーズを示します.
- 伝統的中国医学 (TCM) は新鮮な戦略を提示し,Shen-Qi Paste (SQP) は臓欠乏症のような根本的な原因を標的としています.
- SQPのハーブ成分には 抗炎症性,抗酸化性,筋肉保護性があります
研究 の 目的:
- サルコペニアと診断された透析患者におけるShen- Qi Paste (SQP) の有効性と安全性を評価する.
- この研究は2つのセンター,ランダム化,ダブルブラインド,プラセボ制御の臨床試験設計を使用した.
主な方法:
- サルコペニアの128人の透析患者は,SQPまたはプラセボグループにランダムに12週間に分けられました.
- 介入には,口服によるSQP (1本/ 15g1日2回) またはプラセボ,低強度運動が含まれていました.
- 主なアウトカム指標には,骨格筋量指数 (SMI),握り力,身体機能 (座りから立ち上がる5回テスト) が含まれていた.
主要な成果:
- SQPの介入は,SMIを有意に改善し,ミオスタチンと尿酸の血清レベルをベースラインと比較して減少させた.
- プラセボと比較して,SQPはSMIとMini Nutritional Assessmentショートフォームのスコアを顕著に改善しました.
- SQPはまた,ピッツバーグの睡眠品質指数,TCM症候群スコア,C反応性タンパク質,および血中尿素窒素濃度の大幅な減少をもたらしました.
結論:
- シェン・キペースト (SQP) は,筋肉の質量と機能を向上させ,透析患者におけるサルコペニアの有効な治療法を示しています.
- 多様な患者集団におけるSQPの有効性を調査し,その作用メカニズムを明らかにするために,さらなる研究が必要である.
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