IVF 中の 抗生物質 曝露: 助産生殖 の 見過ごされた 変数?
Tatjana Blagojevic1, Barbara Lawrenz2, Erkan Kalafat1
1ART Fertility Clinic Abu Dhabi, United Arab Emirates.
まとめ
卵子採取中の抗生物質の投与は,その後の冷凍胚移植における生育率に影響を与えない. この研究では,抗生物質を服用した女性と服用しなかった女性の妊娠結果において,有意な差は認められませんでした.
科学分野:
- 生殖内分泌学と不妊症
- 産婦人科
- 臨床薬理学
背景:
- 助産生殖技術 (ART) で卵細胞採取の手続き (OPU) の際に抗生物質予防が時々使用されます.
- 後の冷凍胚移植 (FET) の結果,特に進行中の妊娠と生育率に対する手術後の抗生物質の影響は不明である.
研究 の 目的:
- OPU中に一度の静脈内付近手術用抗生物質投与が,一度のユプロイド凍結胚移植 (seFET) の後の進行中の妊娠および生児率に及ぼす影響を調査する.
主な方法:
- 20~35日以内にseFETを受けた676人の女性を対象とした遡及コホート研究.
- 患者は2つのグループに分けられ,OPU中に1回投与された手術後の抗生物質を投与した患者と投与されなかった患者でした.
- 人口統計データ,OPU-FET間隔,および臨床結果が比較されました.
主要な成果:
- 進行中の妊娠や生児の比率は,抗生物質群と抗生物質群の間で有意な差異は見られなかった.
- 胎児の質は妊娠の結果に大きな影響を与えたが,OPU中の手術後の抗生物質の使用は効果を示さなかった.
- ABグループはBMIとAMHの値が高かったが,これらは主要アウトカムを混同しなかった.
結論:
- OPUの間,一度の静脈内付近期抗生物質投与は,妊娠,進行中の妊娠,またはその後のseFETによる凍結戦略における生児率に影響を与えない.
- 胚の質はARTにおける妊娠の成功の決定的な要因です.
- FETの成功率を向上させるには,OPU中の日常的な抗生物質の予防が必要ないことを示唆しています.
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