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関連する概念動画

Tissues01:18

Tissues

80.7K
Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
80.7K
Compartment Models: Two-Compartment Model01:20

Compartment Models: Two-Compartment Model

5.9K
The two-compartment model divides the body into central and peripheral compartments to account for varying blood perfusion rates among organs and tissues, affecting drug distribution. The central compartment includes blood and highly perfused tissues with rapid drug distribution, while the peripheral compartment contains tissues with slower drug distribution. After a single IV bolus dose, the drug concentration is high in plasma and low in tissues. The drug distribution between compartments...
5.9K
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

3.4K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.4K
Three-Compartment Open Model01:06

Three-Compartment Open Model

421
The three-compartment open model is a pharmacokinetic model used to describe the distribution and elimination of drugs following extravascular administration. It comprises a central compartment representing the plasma and two peripheral compartments. The highly perfused peripheral compartment represents organs and tissues with a rich blood supply, such as the liver, kidneys, and lungs. The scarcely perfused peripheral compartment represents tissues with lower blood supply, such as adipose...
421
Dense Connective Tissue01:13

Dense Connective Tissue

8.6K
Dense connective tissue contains more collagen fibers than loose connective tissue. As a consequence, it displays greater resistance to stretching. There are two major categories of dense connective tissue— regular and irregular.
Dense Regular Connective Tissue
In dense regular connective tissue, fibers are arranged parallel to each other, enhancing its tensile strength and resistance to stretching in the direction of the fiber orientations. Ligaments and tendons are made of dense regular...
8.6K
Classification of Epithelial Tissues: Overview01:22

Classification of Epithelial Tissues: Overview

14.7K
Epithelial tissues are classified according to the shape of the cells and the number of cell layers formed. Cell shapes can be squamous (flattened and thin), cuboidal (square-like, as wide as it is tall), or columnar (rectangular, taller than it is wide). Additionally, the nucleus shape helps identify the type of epithelial cells. Squamous cells have flattened disc-shaped nuclei, cuboidal cells have spherical nuclei, and columnar cells have elongated nuclei.
Based on the number of cell layers,...
14.7K

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Updated: Sep 9, 2025

Finite Element Modelling of a Cellular Electric Microenvironment
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Finite Element Modelling of a Cellular Electric Microenvironment

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細胞密度が適度な組織のための連続モデル

Yashar Ebadi1, Elizabeth D Shih2, Victor H Barocas2

  • 1Department of Mechanical Engineering, University of Minnesota - Twin Cities, Minneapolis, MN, USA.

Computers in biology and medicine
|August 31, 2025
PubMed
まとめ
この要約は機械生成です。

新しいハイブリッドモデルは 組織内の細胞ストレスを 異なる密度で正確に予測します これは脳動脈瘤のような状態における 機械伝導の理解を進めている.

キーワード:
脳動脈瘤制限混合モデルエシェルビー溶液FEM について成長と改造混合のルール血管の滑らかな筋肉細胞

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Non-Destructive Evaluation of Regional Cell Density Within Tumor Aggregates Following Drug Treatment
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Non-Destructive Evaluation of Regional Cell Density Within Tumor Aggregates Following Drug Treatment

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Perfusable Vascular Network with a Tissue Model in a Microfluidic Device
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Perfusable Vascular Network with a Tissue Model in a Microfluidic Device

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関連する実験動画

Last Updated: Sep 9, 2025

Finite Element Modelling of a Cellular Electric Microenvironment
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Finite Element Modelling of a Cellular Electric Microenvironment

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Non-Destructive Evaluation of Regional Cell Density Within Tumor Aggregates Following Drug Treatment
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Non-Destructive Evaluation of Regional Cell Density Within Tumor Aggregates Following Drug Treatment

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Perfusable Vascular Network with a Tissue Model in a Microfluidic Device
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科学分野:

  • 生物医学工学
  • 細胞メカニズム
  • 組織工学

背景:

  • 細胞はメカニカル・トランスデュークションを通じて 機械的な力に反応し 組織の発達に不可欠です
  • 既存のモデルは,中程度の細胞密度を持つ組織における細胞のストレスを正確に予測するのに苦労しています.

研究 の 目的:

  • 細胞密度の中間の組織における細胞ストレスを予測するための新しいモデルを開発し,検証する.
  • 細胞の形状,密度,物質の性質が組織ストレスに及ぼす影響を調査する.

主な方法:

  • 有限要素モデリング (FEM) は,異なる細胞形 (球形,円形,円筒形),体積分,および硬度比の組織サンプルをシミュレートするために使用されました.
  • 代表的な体積要素 (RVE) は,単軸伸縮下で組織機構をモデル化するために使用されました.
  • ミックスル (ROM) とエシェルビーのインクルージョンモデルを組み合わせたハイブリッドモデルが開発され,FEMの結果に対して検証された.

主要な成果:

  • 混合のルール (ROM) モデルは低細胞密度で不正確性を示し,エシェルビーのモデルは高密度で不確実性を示した.
  • 提案されたハイブリッドモデルは,FEMと比較して,幅広い細胞密度における細胞ストレスを予測する上で優れた精度を示した.
  • ハイブリッドモデルは,複雑な非線形物質の性質を持つ組織におけるストレスを効果的に捉えました.

結論:

  • 開発されたハイブリッドモデルは,中間の細胞密度を持つ組織における細胞ストレスをモデル化するためのより正確で汎用的なアプローチを提供します.
  • この研究は,脳動脈瘤を含む様々な生理学的および病理学的状態における機械伝導の理解を高める.
  • このモデルは組織力学を研究し,治療戦略を導くために貴重なツールを提供します.