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Updated: Sep 9, 2025

Screening Peptides that Activate MRGPRX2 using Engineered HEK Cells
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トリプテリギウム・ウィルフォードフックFの活性成分は,MASに関連するGタンパク質結合受容体X2を通じてアナフィラクトイド反応を緩和する

Na Guo1, Haoyun Bai1, Lu Cao1

  • 1School of Pharmacy, Health Science Center, Xi'an Jiaotong University, 76# Yanta West Road, Xi'an, 710061, China; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, China.

Talanta
|August 31, 2025
PubMed
まとめ

伝統的な中国薬のトリプテリジウム・ウィルフォードフックF (TwHF) には,MASに関連するGタンパク質結合受容体X2 (MRGPRX2) を標的とする化合物が含まれています. これらの化合物は,炎症媒介体およびマスト細胞の脱粒化を阻害することによって,アナフィラクトイド反応の治療の可能性を示しています.

キーワード:
アナフィラクトイド反応細胞膜染色学MAS関連Gタンパク質結合受容体X2トリプテリギウム・ウィルフォード フックF

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