妊婦および出産後の早期の抗生物質投与は,再発性自閉症スペクトル障害のリスクを増加させる可能性があります
Boli Cheng1, Xi Lai2, Huan Liu3
1Department of Pediatrics, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong 637000, China.
Neurotoxicology and teratology
|August 31, 2025
まとめ
妊娠および幼児期における抗生物質投与は,再発性自閉症スペクトル障害 (ASD-R) のリスクを増加させる可能性があります. ASD-Rの子どもは抗生物質への曝露率が高く,これは再発の危険因子であり,症状がより深刻になる可能性があることを示唆しています.
科学分野:
- 神経発達障害
- 小児の健康
- 薬理学について
背景:
- 自閉症スペクトル障害 (ASD) は複雑な神経発達状態です.
- 以前習得したスキルの喪失が特徴である.
- 自閉症の潜在的環境リスク因子 (ASD-R) を理解することは,早期の介入に不可欠です.
研究 の 目的:
- 妊娠中の抗生物質の投与と産後初期における抗生物質の投与とASD-Rのリスクとの関連を調査する.
- 抗生物質の曝露がASDの子供における主要な症状の重さに影響するかどうかを判断する.
主な方法:
- ASDと診断された483人の子どもを対象としたケース・コントロール研究です.
- 子供たちは,ASDと再帰 (ASD- R) と再帰のないASD (ASD- NR) のグループに分けられました.
- 介護者が報告したアンケートでは,妊婦の妊娠期および産後期初期における抗生物質使用が評価されました.
主要な成果:
- ASD-Rグループは,ASD-NRグループと比較して,妊娠中のASD-Rグループ (10. 3%) と2歳未満 (44. 0%) で著しく高い割合で抗生物質を投与した.
- 母親の抗生物質投与は,ASDの子供における再発の可能性が高くなった (調整されたOR=3. 36).
- また,早産後の抗生物質投与は,ABCスケールで測定したより重度のコア症状と関連しており,再発のリスクを高めました (調整 OR = 1. 50).
結論:
- ASD-Rの子どもでは,妊娠中および出産後の早期に抗生物質への曝露率が高かった.
- ASDの子供における抗生物質の暴露は,重要なリスク要因である可能性があります.
- 抗生物質被曝歴はASDの主要な症状の重症化と相関する可能性があります.
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