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Updated: Apr 18, 2026

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Gnetupendin Aは,AMPK/SIRT1経路を通じた酸化ストレスを調節することによって,不全性脳卒中の損傷を軽減する

Dequan Wang1, Danyang Mu1, Yan Mi1

  • 1Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, National Frontiers Science Center for Industrial Intelligence and Systems Optimization, Key Laboratory of Data Analytics and Optimization for Smart Industry, Ministry of Education, Northeastern University, Shenyang 110000, China.

Biochemical pharmacology
|August 31, 2025
PubMed
まとめ

Gnetupendin A (GA) は,酸化ストレスを軽減することによって,脳性缺血再注射損傷 (CIRI) に対して保護します. GAはNADPH酸化酵素 (NOX) 2を標的にし,AMPK/SIRT1経路を通じてミトコンドリア機能を保ち,神経保護を提供します.

キーワード:
AMPK/SIRT1についてグネトゥペンドインA発血性脳卒中ミトコンドリア機能障害NOX2 について酸化ストレス

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