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Updated: Sep 9, 2025

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
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α7nAChRの活性化は,IP3R/Ca2+/カルシヌーリンの経路経由でFoxo1の脱リン酸化を強化することによってTreg細胞の生成を促進する

Yue He1, Yanrong Zhu1, Yilei Guo1

  • 1Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Long Mian Avenue, Nanjing 211198, China.

Biochemical pharmacology
|August 31, 2025
PubMed
まとめ

アルファ7ニコチンアセチルコリン受容体 (α7nAChR) の活性化は,IP3R/ Ca2+/ カルシヌーリンの経路経由で調節性T細胞 (Treg) の分化を促進する. このメカニズムは自己免疫疾患の 治療対象となる可能性があります

キーワード:
カルシヌーリンフォックス1IP3R についてトレグ細胞α7nAChR

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