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Updated: Sep 9, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

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単一胃区間の設定による数学モデルから胃溶解の推定を改善するためのバイオ医薬品における新しいアプローチの探索:クアゼパムの食物効果に対する胃溶解の影響

Jia Liu1, Michael J Dolton2, Karthik Nagapudi1

  • 1Small Molecule Pharmaceutical Sciences, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

Journal of pharmaceutical sciences
|August 31, 2025
PubMed
まとめ

経口薬の吸収予測を改善するこの研究は,pHに依存する胃溶解性を統合することによって,薬理動態 (PK) モデルを強化します. このアプローチは,pKa値が低い基本的な薬に対する食品の影響を正確に評価します.

キーワード:
食品の影響吸収された分数モデリング口服するクアゼパム胃について

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