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Updated: Sep 9, 2025

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
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Published on: June 23, 2019

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強力で選択的なROCK2阻害剤として,4-(2-メトキシフェニル) -1H-ピラゾール基板を持つA20の発見

Junzheng Wang1, Bin Peng1, Guodong Liang1

  • 1Key Laboratory for Candidate Medicine Design and Screening Based on Chemical Biology, College of Pharmacy, Inner Mongolia Medical University, Hohhot, PR China.

Bioorganic & medicinal chemistry letters
|August 31, 2025
PubMed
まとめ

研究者は,神経疾患と線維症における重要なタンパク質であるRho関連タンパク質キナーゼ2 (ROCK2) を標的とする化合物を最適化しました. 新しい化合物A20は 強力なROCK2阻害を示し 治療上の利点をもたらします

キーワード:
分子ドッキングROCK2阻害剤構造と活動の関係合成

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