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Updated: Sep 9, 2025

Characterization of a Novel Human Organotypic Retinal Culture Technique
05:51

Characterization of a Novel Human Organotypic Retinal Culture Technique

Published on: June 9, 2021

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TNF-α-OTUD3-PPARγ信号軸の調節不良は,糖尿病性網膜病における網膜酸化ストレスと炎症を悪化させる

Jialin Zhang1, Zhen Wang2, Junjun Liu1

  • 1Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Central Hospital Affiliated to Shandong First Medical University, Jinan 250013, Shandong Province, China.

Life sciences
|August 31, 2025
PubMed
まとめ

卵巣腫瘍ドメイン含有タンパク質3 (OTUD3) は,ペロキシソーム増殖器活性化受容体 γ (PPARγ) を調節することによって,糖尿病性網膜病変 (DR) に対して保護します. この研究は,主要な糖尿病合併症であるDRの潜在的な治療標的としてOTUD3を特定しています.

キーワード:
糖尿病性網膜症OTUD3 について酸化ストレスPPARγ についてTNF-α

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