血清ビタミンDと卵巣の貯蔵量との関連性 助産生殖技術を受けた女性
Longbao Xu1, Lanlan Fang1, Mengyao Gao1
1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; The Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.
The Journal of nutrition
|August 31, 2025
まとめ
この研究では,女性の25-ヒドロキシビタミンD (25-OHビタミンD) レベルが高くなり,女性の卵巣の健康にビタミンDのポジティブな役割を示唆しています.
科学分野:
- 生殖内分泌学
- 栄養学
- 不妊 症 研究
背景:
- インビトロおよびインビボの研究では,25-ヒドロキシビタミンD (25-OHビタミンD) が卵巣の貯蔵量に好影響を及ぼすことが示唆されています.
- 集団ベースの研究では,ビタミンDと卵巣貯蔵量に関する不一致な結果が出ています.
研究 の 目的:
- 血清の25-OHビタミンD濃度と卵巣の主要なリザーブマーカーの関連性を調査する.
- ビタミンDと卵巣貯蔵量減少 (DOR) のリスクを評価する.
主な方法:
- 助産生殖治療を受けている1488人の女性 (年齢20~50歳) の横断的な研究.
- アンチムレリアンホルモン (AMH),アントラル卵泡数 (AFC),および卵泡刺激ホルモン (FSH) を用いて測定した卵巣準備量.
- プアソン回帰,線形回帰,ロジスティック回帰,制限された立方スプレインを含む統計モデルが使用されました.
主要な成果:
- 25- OHビタミンDとAFC (p<0. 05) の間に有意な正の相関が観察されました.
- ボディ・マス・インデックス (BMI) は,25- OHビタミンDとAFCとの関連性を有意に変化させ,陽性なリンクは低いBMI (<24 kg/ m2) の個体においてのみ明らかになった.
- 非線形で反転したU型関係は,25- OHビタミンDレベルとFSH (p<0. 05) の間で確認された.
結論:
- 血清の25-OHビタミンDレベルは,葉数の増加と関連しています.
- 卵泡刺激ホルモン (FSH) レベルは,25-OHビタミンDの増加とともに,逆のU型傾向を示しています.
- これらの発見は,女性の生殖健康を維持する 25-OH ビタミンDの潜在的な有益な役割を支持しています.
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