小児臨床研究への入学率と留学率を高める戦略: スコーピングレビュー
Miguel A Pena1,2,3, Melicia Y Whitley4, Anirudh Sudarshan1,5
1Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts.
Pediatrics
|August 31, 2025
まとめ
多様な小児科の参加者を募るには 多種多様な研究段階が必要です 戦略は信頼を築き,インセンティブを提供し,継続的なフィードバックを使用して,臨床試験への登録と留守を改善することに重点を置くべきです.
科学分野:
- 小児臨床研究
- 健康に関する公平性
- 臨床試験の設計
背景:
- 小児臨床研究における多様性の欠如は,研究結果の一般化を制限する.
- 健康上の不平等は 多様性のない研究参加によって悪化する可能性があります
- 効果的な戦略を特定することは 包摂的な小児科研究に不可欠です
研究 の 目的:
- 臨床研究における小児の参加者多様性を改善するための根拠に基づいた戦略を特定する.
- 小児科の臨床研究プロトコルをガイドするツールを開発し,より良い入学と留学を可能にします.
- 小児臨床研究の参加者募集と留守における障壁を解決する.
主な方法:
- 2009年から2022年までのピアレビューされた文献のスコーピングレビュー.
- スコーピングレビューのためのPRISMA拡張 (体系的なレビューとメタ分析のための優先報告項目) をフォローしました.
- 定量的な結果と質的な結果を分析し,消耗段階によって発見を分類した.
主要な成果:
- 31件の研究が含有基準を満たし,結果は研究設計,マーケティング,参加者の認識,同意,インセンティブ,維持,フォローアップに分類されました.
- 多重な消耗カテゴリーが特定され,小児の参加者登録と維持に複雑な課題が指摘された.
- ほとんどの研究はランダム化されていないため,戦略の直接比較に課題が生じた.
結論:
- 多様な小児科の集団を効果的に採用するには,すべての研究段階にわたる包括的なアプローチが必要です.
- 戦略は信頼の構築を優先し,適切なインセンティブを提供し,継続的なフィードバックメカニズムを統合する必要があります.
- 多面的な戦略は,成功する小児臨床研究参加者の多様性にとって不可欠です.
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