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関連する概念動画

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Absorption of Radiation01:05

Absorption of Radiation

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The rate of heat transfer by emitted radiation is described by the Stefan-Boltzmann law of radiation:
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Radiation: Applications01:17

Radiation: Applications

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The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
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Biological Effects of Radiation02:59

Biological Effects of Radiation

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All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
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Mutations01:35

Mutations

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Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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カピヴァサーチブ投与後の放射線リコール皮膚炎

Yuhao Shi1, Ian W Tattersall2, Boris Kobrinsky3

  • 1Department of Radiation Oncology, New York University Grossman School of Medicine, New York, New York.

Practical radiation oncology
|August 31, 2025
PubMed
まとめ
この要約は機械生成です。

PI3K/ Akt経路の阻害剤であるキャピバサーチブを投与された患者で,転移性乳がんの治療で,放射線リコール性皮膚炎が発生した. この珍しい副作用は,以前に放射線治療を受けた患者にカピヴァサーチブを使用する際の注意の必要性を強調しています.

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Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
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Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
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Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
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Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
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科学分野:

  • 腫瘍学
  • 薬理学について

背景:

  • 放射線リコール皮膚炎は珍しい副作用です.
  • カピヴァサーチブはPI3K/ Akt経路阻害剤で,乳がんの治療に承認されています.
  • 緩和放射線に対する安全性は不明である.

研究 の 目的:

  • 放射線性皮膚炎を報告する
  • 放射線治療を受けた患者に対するカピヴァサーチブの安全性について議論する.

主な方法:

  • 転移した乳がん患者の症例報告
  • 患者の下肢を放射線で照射した後にカピヴァサーチブを投与した.

主要な成果:

  • 患者は放射線による皮膚炎を発症しました
  • 治療にはコルチコステロイド,抗生物質,アルペリシブへの切り替えが含まれていた.

結論:

  • カピヴァサーチブは放射線リコール皮膚炎を引き起こす可能性があります.
  • 過去に放射線治療を受けた患者の場合,カピヴァサーチブを使用する際には注意が必要です.