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Updated: Sep 9, 2025

Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation
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Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation

Published on: June 21, 2021

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N端のシステイン酸化素基質の偏好を研究するための生体物理的アプローチ

Karishma Patel1, Yannasittha Jiramongkol2, Mark D White3

  • 1School of Chemistry, The University of Sydney, Sydney, NSW, Australia; School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia.

Methods in enzymology
|August 31, 2025
PubMed
まとめ

N終端システイン酸化酵素 (NCOs) は,N-デグロン経路経由でタンパク質の安定性を調節する酸素センサーとして作用する. この研究は,哺乳類のNCOの基板への結合を分析するために表面プラズモン共鳴 (SPR) を使用し,酵素基板相互作用を明らかにします.

キーワード:
ADO について低酸素症N-デグロン経路N端のシステイン酸化酸素翻訳後の修正プロテイン・ターミナルサブストラット結合表面プラズモンの共鳴

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