関連する実験動画

Updated: Sep 9, 2025

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
12:15

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter

Published on: May 29, 2019

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インド北部のパンジャブ州の農薬にさらされた農作業員におけるDNA損傷に対する感受性のバイオマーカーとしてのDNA修復遺伝子におけるエピスタティック相互作用

Karashdeep Kaur1, Rupinder Kaur2

  • 1Viral Research and Diagnostic Laboratory (VRDL), Government Medical College, Patiala, Punjab 147001, India; Department of Biotechnology, Sri Guru Granth Sahib World University, Fatehgarh Sahib, Punjab 140406, India.

Mutation research. Genetic toxicology and environmental mutagenesis
|August 31, 2025
PubMed
まとめ

DNA修復遺伝子の遺伝的変異は 農薬によるDNA損傷を 顕著に増加させます これらの遺伝子相互作用は 農薬への曝露感受性のバイオマーカーとして機能する.

キーワード:
バイオマーカーDNA 損傷DNA 修復エピスタティック相互作用遺伝子ポリモルフィズム農薬への曝露

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In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
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