関連する実験動画

Updated: Sep 9, 2025

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

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固体中の薬剤の光安定性評価のためのUVプローブを装備した同熱差分スキャニングカロミテリーの適用

Seiji Haruna1,2, Eita Shimoda3, Hiromasa Uchiyama1

  • 1Department of Formulation Design and Pharmaceutical Technology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, Osaka 569-1094, Japan.

Chemical & pharmaceutical bulletin
|August 31, 2025
PubMed
まとめ

紫外線探知器 (フォト-DSC) を使った同熱差スキャン熱計は,医薬品の光安定性を評価するための新しい方法を提供します. この技術は,光分解のリアルタイム観測を可能にし,従来の方法よりも効率的で環境に優しい代替手段を提供します.

キーワード:
1,4-ジヒドロピリジンイソテルミック・ディフェンシャル・スキャニング・カロメトリフォト・ディファレンシャル・スキャニング・カロメトリー (フォト・DSC)

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UV–Vis Spectrometers01:14

UV–Vis Spectrometers

The absorbance of UV and visible (UV–visible) radiations is measured using a UV–visible spectrophotometer. Deuterium lamps, which emit UV radiation, and tungsten lamps, which produce radiation in the visible region, are used as light sources in UV–visible spectrophotometers. A monochromator or prism is used for diffraction grating, i.e., to split the incoming radiation into different wavelengths. A system of slits is used to focus the desired wavelength on the sample cell.
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Ultraviolet–visible (UV–visible or UV–Vis) spectroscopy is an analytical technique that investigates the interaction between matter and UV–Vis light within the electromagnetic spectrum. This method is widely used for its versatility, simplicity, and relatively quick data acquisition, making it valuable for both qualitative and quantitative analysis. When UV–Vis radiation passes through a material,  molecules absorb light depending on the energy required for...
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In a flame photometer, when a solution like potassium chloride is aspirated into the flame, the solvent evaporates, leaving behind dehydrated salt. This salt dissociates into free gaseous atoms in their ground state. Some of these atoms absorb energy from the flame, leading to their excitation. The excited atoms return to the ground state, emitting photons at characteristic wavelengths. Because only electronic transitions are involved, the resulting emission lines are very narrow. The intensity...
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