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関連する概念動画

Drug Delivery: Overview01:16

Drug Delivery: Overview

422
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
422
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

467
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
467
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

827
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
827
Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport01:23

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

788
Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
788
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

709
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
709
Prodrugs01:30

Prodrugs

2.8K
Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
Prodrugs help overcome...
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Updated: Sep 9, 2025

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
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[新しいコンセプトに基づく薬物投与システムの開発]

Chikamasa Yamashita1

  • 1Department of Pharmaceutics and Drug Delivery, Faculty of Pharmaceutical Sciences, Tokyo University of Science.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
|August 31, 2025
PubMed
まとめ
この要約は機械生成です。

このレビューは 40年にわたる医薬品研究を強調し,革新的な薬物投与システムに焦点を当てています. 重要な発展には,新しい吸入,COPD,アルツハイマー病が含まれています.

キーワード:
鼻から脳へアクソナル輸送慢性閉塞性肺疾患凍結乾燥ケーキ吸入する脂質ナノ粒子

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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
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関連する実験動画

Last Updated: Sep 9, 2025

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
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科学分野:

  • 医薬品科学
  • 薬物投与システム
  • 再生医療

背景:

  • オツカ 製薬 株式会社 と 東京 科学 大学 の 40 年 の 研究 開発 の 概要
  • 臨床的意義と新薬投与システムのコンセプトに焦点を当てて,従来の考え方に挑戦します.

研究 の 目的:

  • 主要な研究プロジェクトと 薬物投与に対する革新的なアプローチをまとめます
  • 患者中心の吸入システム,慢性閉塞性肺疾患 (COPD) 治療,アルツハイマー病の治療法の進歩を紹介する.

主な方法:

  • 患者の観点からタンパク質の供給のための新しい吸入システムの開発.
  • COPDにおけるアルベオラの再生のための脂質ナノ粒子による核移転戦略の活用
  • アルツハイマー病の薬の開発のためのグリコシル化鼻から脳へのシステムの設計.

主要な成果:

  • 患者中心のタンパク質吸入システムの概念化と説明
  • アルベオラの再生を伴うCOPDの根本的な治療戦略の提案
  • アルツハイマー病の治療薬を鼻経由で脳に届けるための特殊なシステムの開発

結論:

  • 研究は,革新的な薬剤の提供を通じて臨床的ニーズに対応するための一貫したコミットメントを示しています.
  • 記述されたシステムは,伝統的な薬学的なアプローチを超えて,重要な概念的シフトを表しています.
  • COPDとアルツハイマー病の将来の治療薬は,これらの新しい投与戦略から利益を得ることができます.