[新しいコンセプトに基づく薬物投与システムの開発]

Chikamasa Yamashita¹

¹Department of Pharmaceutics and Drug Delivery, Faculty of Pharmaceutical Sciences, Tokyo University of Science.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

|August 31, 2025

まとめ

このレビューは 40年にわたる医薬品研究を強調し,革新的な薬物投与システムに焦点を当てています. 重要な発展には,新しい吸入,COPD,アルツハイマー病が含まれています.

科学分野:

医薬品科学
薬物投与システム
再生医療

背景:

オツカ製薬株式会社と東京科学大学の 40 年の研究開発の概要
臨床的意義と新薬投与システムのコンセプトに焦点を当てて,従来の考え方に挑戦します.

研究の目的:

主要な研究プロジェクトと薬物投与に対する革新的なアプローチをまとめます
患者中心の吸入システム,慢性閉塞性肺疾患 (COPD) 治療,アルツハイマー病の治療法の進歩を紹介する.

主な方法:

患者の観点からタンパク質の供給のための新しい吸入システムの開発.
COPDにおけるアルベオラの再生のための脂質ナノ粒子による核移転戦略の活用
アルツハイマー病の薬の開発のためのグリコシル化鼻から脳へのシステムの設計.

主要な成果:

患者中心のタンパク質吸入システムの概念化と説明
アルベオラの再生を伴うCOPDの根本的な治療戦略の提案
アルツハイマー病の治療薬を鼻経由で脳に届けるための特殊なシステムの開発

結論:

研究は,革新的な薬剤の提供を通じて臨床的ニーズに対応するための一貫したコミットメントを示しています.
記述されたシステムは,伝統的な薬学的なアプローチを超えて,重要な概念的シフトを表しています.
COPDとアルツハイマー病の将来の治療薬は,これらの新しい投与戦略から利益を得ることができます.

キーワード:

鼻から脳へアクソナル輸送慢性閉塞性肺疾患凍結乾燥ケーキ吸入する脂質ナノ粒子

さらに関連する動画

18:57

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

46.6K

09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

16.0K

関連する概念動画

01:16

Drug Delivery: Overview

422

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...

422

01:22

Drug Delivery: Miscellaneous Routes

467

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...

467

01:29

Drug Delivery: Parenteral Route

827

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

827

01:23

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

788

Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...

788

01:18

Drug Delivery: Enteral Route

709

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.

709

01:30

Prodrugs

2.8K

Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
Prodrugs help overcome...