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Updated: Sep 9, 2025

Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish
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Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish

Published on: April 16, 2019

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抽出剤および浸出剤 (E&L) の静脈内TTC (TTCiv) の推定は,オープンソースPBPKモデルを使用して予測された血液濃度に基づく修正因子を適用することによって行う

Tae Hayashi1, Akira Kotaki1, Asako Fukushima1

  • 1Chemicals Assessment and Research Center, Chemicals Evaluation and Research, Institute, Japan (CERI).

The Journal of toxicological sciences
|August 31, 2025
PubMed
まとめ

この研究は,医薬品の抽出剤および浸出剤 (E&Ls) に対する静脈内曝露 (TTCiv) の毒理学的懸念基準を確立しています. TTCivは27μg/日/人であり,患者の安全のためにリスク管理を助けます.

キーワード:
E&L について静脈内TTCPDE について

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