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Updated: Sep 9, 2025

In Vitro Assay for Studying the Aggregation of Tau Protein and Drug Screening
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ISRIBは,TIA-1の相分離をVitroで調節することで,その集積を促進する

Miyu Murata1, Hitomi Kimura1,2, Shin-Ichi Tate1,2,3,4

  • 1Department of Mathematical and Life Sciences, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, Japan.

Biological & pharmaceutical bulletin
|August 31, 2025
PubMed
まとめ

統合ストレス反応阻害剤 (ISRIB) は,TIA-1タンパク質の結合をインビトロで強化する. RNA結合は,この効果を緩和し,ISRIBは,RNAに依存した方法でストレス粒子の性質を変更することを示唆する.

キーワード:
RNA結合タンパク質T細胞内抗原-1集積する統合ストレス反応阻害剤液体・液相分離ストレス・グラニュル

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Regulation of the Unfolded Protein Response01:31

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Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
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