ビタミンD欠乏症は,中国人の2型糖尿病患者のマクロアルブミヌリアのリスク増加と関連している
1Department of Endocrinology, The Second Affiliated Hospital of Soochow University.
Journal of nutritional science and vitaminology
|August 31, 2025
まとめ
ビタミンD欠乏症は2型糖尿病患者でよく見られる. 低ビタミンDレベルはアルブミヌーリアの増加と相関し,重度の腎臓損傷 (マクロアルブミヌーリア) のリスクを高めます.
科学分野:
- 内分泌学
- 腎臓科
- 栄養学
背景:
- 2型糖尿病 (T2DM) は腎臓の合併症と関連しています.
- アルブミヌリアは糖尿病性腎臓病の主要なマーカーです.
- ビタミンD欠乏症は様々な慢性疾患で一般的です.
研究 の 目的:
- T2DM患者における血清25-ヒドロキシビタミンD [25[OH]D]濃度とアルブミヌリアの相関を調査する.
- アルブミヌリアの異なる段階におけるビタミンD欠乏症のリスクを評価する.
主な方法:
- 203人の入院T2DM患者の横断的な研究.
- 尿アルブミン対クレアチニン比率 (UACR) に基づいた分類.
- スピアマン相関,複数の回帰,およびロジスティック回帰分析が行われました.
主要な成果:
- ビタミンD欠乏症は患者の59. 1%で観察された.
- 低25OH) D濃度はマクロアルブミヌリアと有意に関連していた (p<0. 001).
- 25 ((OH) DとUACR (r=- 0. 173, p=0. 014) の間には負の相関が認められた.
- ビタミンD欠乏症はマクロアルブミヌリアのリスクを増加させた (OR=4. 747, p<0. 05).
結論:
- ビタミンD欠乏症はT2DM患者で非常に一般的です.
- 低血清25OH) D濃度はアルブミヌリアの増加と関連しています.
- ビタミンD欠乏症はT2DMにおけるマクロアルブミヌリアの重要な危険因子です.
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