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関連する概念動画

Regulation of Metabolism01:19

Regulation of Metabolism

9.8K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
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Thermoregulation01:26

Thermoregulation

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The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
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Energy Balance01:19

Energy Balance

540
The human body gets energy from the three macronutrients: carbohydrates, proteins, and fats. Energy is released when the chemical bonds in the organic compounds present in the food are broken down. The energy content of food is measured in kilocalories (kcal), defined as the amount of heat required to raise the temperature of one kilogram of water by one degree Celsius. This value is determined by measuring the temperature change of the water surrounding a calorimeter after the complete...
540
Regulation of Food Intake01:30

Regulation of Food Intake

350
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
350
Hormones Regulating Blood Glucose01:16

Hormones Regulating Blood Glucose

4.0K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
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Thermosensation01:43

Thermosensation

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Extraction and Analysis of Taiwanese Green Propolis
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Extraction and Analysis of Taiwanese Green Propolis

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ブラジル の グリーン プロポリス は 2 つの 異なる 経路 で 熱生成 を 調節 する

Takuma Hyodo1, Nobuaki Okumura1, Takanori Tsuda2

  • 1Institute for Bee Products and Health Science, Yamada Bee Company Inc.

Journal of nutritional science and vitaminology
|August 31, 2025
PubMed
まとめ

ブラジルの緑のプロポリス (BGP) は2つの異なる発熱経路を活性化します. クリフォリン (BGP成分) はTRPV1経由で茶色脂肪組織 (BAT) の熱生成を刺激し,アルテピリンCはベージュ色脂肪細胞の形成を促し,エネルギー消費を増加させます.

キーワード:
ブラジルの緑のプロポリスベージュの脂肪細胞ブラウンアディポサイトクリフォリン熱生成臨時受容体ポテンシャルバニロイド 1解離タンパク質 1

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Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads
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Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells
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関連する実験動画

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Extraction and Analysis of Taiwanese Green Propolis
06:50

Extraction and Analysis of Taiwanese Green Propolis

Published on: January 7, 2019

8.6K
Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads
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Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells
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Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells

Published on: March 28, 2013

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科学分野:

  • 代謝に関する研究
  • 脂肪組織生物学
  • 自然製品化学

背景:

  • ブラジルの緑のプロポリス (BGP) は代謝を加速し,ベージュ色の脂肪細胞を誘発する.
  • 主要なBGP化合物であるアルテピリンC (ArtC) は,白色脂肪組織におけるベージュ色脂肪細胞の形成と熱生成を促進する.
  • ベージュの脂肪細胞の形成とエネルギー代謝に対するBGPの正確なメカニズムについては,さらなる解明が必要である.

研究 の 目的:

  • ベージュ色脂肪細胞の形成と発熱に対するBGPの影響を調査する.
  • これらの効果の原因となるBGPの特定の成分を特定する.
  • BGP媒介による発熱に関与する分子経路を解明する.

主な方法:

  • インビトロ細胞培養と分化アッセイ
  • コンポーネントテストと熱生成測定を含むインビボ試験
  • TRPV1チャネルを標的としたカルシウム流入測定と抑制試験

主要な成果:

  • アルテピリンC (ArtC) はベージュ色脂肪細胞の形成を促す主要なBGP成分として確認されました.
  • 甲状腺間茶色脂肪組織 (iBAT) のBGP誘発熱生成はArtCによって媒介されませんでした.
  • 別のBGP誘導体であるキュリフォリンは,TRPV1交感神経系経路経由でiBAT発熱の活性化剤として特定され,BGPと同様にiBAT温度を上昇させた.

結論:

  • BGPは,ベージュの脂肪細胞形成 (ArtC経由) と茶色の脂肪細胞生成 (キュリフォリン経由) の2つの別々の発熱経路を独占的に活性化します.
  • クリフォリンのiBATにおけるTRPV1シグナルの活性化は,BGPの熱生成効果に大きく寄与する.
  • BGPは,茶色とベージュの脂肪組織の両方を含む明確なメカニズムを通じてエネルギー消費を増加させます.